Pituitary dwarfism in German Shepherd dogs.

نویسندگان

  • G S Allan
  • C R Huxtable
  • C R Howlett
  • R C Baxter
  • B Duff
  • B R Farrow
چکیده

· Growth hormone (GH), which is essential for growth · Thyroid stimulating hormone (TSH), which regulates thyroid function · Prolactin (PRL), which is essential for lactation · Follicle stimulating hormone (FSH) and Luteinizing hormone (LH), which are essential for ovulation in female animals and sperm production in male animals · Adrenocorticotroph hormone (ACTH), which stimulates the adrenal cortex

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منابع مشابه

Pituitary Dwarfism in Saarloos and Czechoslovakian Wolfdogs is Associated with a Mutation in LHX3

BACKGROUND Pituitary dwarfism in German Shepherd Dogs is associated with autosomal recessive inheritance and a mutation in LHX3, resulting in combined pituitary hormone deficiency. Congenital dwarfism also is encountered in breeds related to German Shepherd Dogs, such as Saarloos and Czechoslovakian wolfdogs. OBJECTIVES To investigate whether Saarloos and Czechoslovakian wolfdog dwarfs have t...

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A Contracted DNA Repeat in LHX3 Intron 5 Is Associated with Aberrant Splicing and Pituitary Dwarfism in German Shepherd Dogs

Dwarfism in German shepherd dogs is due to combined pituitary hormone deficiency of unknown genetic cause. We localized the recessively inherited defect by a genome wide approach to a region on chromosome 9 with a lod score of 9.8. The region contains LHX3, which codes for a transcription factor essential for pituitary development. Dwarfs have a deletion of one of six 7 bp repeats in intron 5 o...

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Atlanto‐Axial Malformation and Instability in Dogs with Pituitary Dwarfism due to an LHX3 Mutation

BACKGROUND Canine pituitary dwarfism or combined pituitary hormone deficiency (CPHD) in shepherd dogs is associated with an LHX3 mutation and can lead to a wide range of clinical manifestations. Some dogs with CPHD have neurological signs that are localized to the cervical spine. In human CPHD, caused by an LHX3 mutation, anatomical abnormalities in the atlanto-axial (C1-C2) joint have been des...

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Age-dependent electrocardiographic and echocardiographic changes in German Shepherd dogs

By causing numerous changes in the cardiovascular system, ageing leads to a decreased threshold for clinical manifestation of heart disease. The aim of this study was to define the existence of cardiac structural and functional changes in healthy dogs of different age. Radiographic, electrocardiographic (ECG) and echocardiographic examinations of 20 clinically healthy German Shepherd dogs were ...

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عنوان ژورنال:
  • The Journal of small animal practice

دوره 19 12  شماره 

صفحات  -

تاریخ انتشار 1978